SUPERVISORS |
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| Supervisor - 1 | Prof Yang Chun, Charles |
| Supervisor - 2 | - |
DETAILS |
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| Proj No | A017 |
| Title | MEMS filter for Cell separation with novel dielectrophoresis force enhancement |
| Objective | To develop and characterize MEMS filter for biological cell enrichment |
| Scope | Microfluidics based MEMS systems are extensively used for detecting food pathogen and chemical and biological warfare agents. In addition, microfluidic systems can be used in the molecular analysis of cancer cells to provide cancer prognostic information. One of the key issues is to process cell samples in a microfluidic structure so as to differentiate, separate and sort cells according to their characteristic phenotypes. MEMS based micro filters have advantages including small dead volume and cost effective. However, existing MEMS filters suffer numerous disadvantages such as blocking the filter mash, cell deforming and passing through the filter. A new MEMS filter device that combines dielectrophoresis and microfluidics based hydrodynamic force will be developed. In this design, variation in dielectrophoresis forces can be produced through microfabricated electrodes to manipulate the cell motion in combination with hydrodynamic forces, and then the separation of cells can be achieved. |
| Prerequisites | The project will be conduced in Institute of Bioengineering and Nanotechnology (IBN)(http://www.ibn.a-star.edu.sg). Students with good academic record and willingness of traveling are encouraged to apply. |
| Area - 1 | Controls |
| Area - 2 | Measurements |
| Area - 3 | Fluid Mechanics |
| Category | Design and Development |
| SRP | Bio-Micro Electro-Mechanical System (Bio-MEMS) |
| Stream | Mechatronics |
| ISP | No |
WEIGHTAGE |
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| Literature Survey | 15 |
| Design | 30 |
| Fabrication and testing | 30 |
| Laboratory/site investigation | 25 |